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doi: 10.3389/fnut.2025.1686056 Received 14 August 2025 Accepted 25 September 2025 Published 16 October 2025 Volume 12 - 2025 Edited by Mingyue Song, South China Agricultural University, China Reviewed by Ludovica Verde, University of Naples Federico II, Italy Arely Vergara-Castaeda, La Salle University of Northwest, Mexico Updates Copyright 2025 Chyliska and Maciejczyk

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are also at risk for Alzheimers/Parkinsons This may be related to inflammation leading to the release of pro-inflammatory cytokines that cross the Blood Brain Barrier causing neural inflammation and thus aggregation of amyloid plaques Brain inflammation in the brain also trigger Prostaglandins E2 inhibits your brains ability to release Serotonin (can cause depressive symptoms and other problems beyond mood) Children with autism also tend to have problems with their microbiome and inflammation in your gut which also leads to inflammation in the brain Sense of Smell is a good predictor of Alzheimers and even all-cause mortality The Olfactory Bulb requires a constant supply of neural stem cells coming from the subventricular zone When you cant supply this, you cant smell anymore = you lack neural stems cells which means you can no longer make new connections in the brain Joe knows people (Gary Goodrich) who were knocked out and lost their sense of smell Study giving young blood from mice to old mice: Can stimulate stem cells in mice and making them younger ( NOT translatable to humans sorry ) Twilight/Dracula fans Found they could isolate a specific growth factor, just inject that and get same results in mice A new study in Stanford trying this in humans people with mild AD Chris Henry (football player): Autopsy of his brain looked like a 70 year old AD patients he was 26 (likely due to chronic brain damage) 76/79 NFL players whos brains were evaluated after death has significant amyloid plaque build-up Junior Seau shot himself in heart so his brain could be examined Looks like some NFL players are getting the message: NFL rookie retiring at 24 because the next hit might kill me Impulsive behavior is related to neuro-degenerative diseases (but many fighters are impulsive to begin with so might already have issues here) Self-directed (suicide) or towards others Lack of long term planning Serotonin plays a big role in regulating impulsivity If you acutely flood the brain with serotonin, you can acutely decrease impulsive behavior (2010 study) unclear this can be done for long term Key Chemicals/Supplements for Brain Health Glutathione : Major brain antioxidant Key for brain aging, more tends decrease AD/damage/etc