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This modification affects chromatin structure and regulates gene expression

Rajagopal Sekhar, associate professor of medicine in the Section of Endocrinology, Diabetes and Metabolism at Baylor

In particular, lysosomal cholesterol accumulation may predispose to APAP hepatotoxicity by a dual mechanism involving the impairment of mitophagy in hepatocytes and the disruption of TLR9 trafficking in LSEC