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GHK-Cu GHK-Cu, or Glycyl-L-Histidyl-L-Lysine Copper Complex, is a naturally occurring copper peptide first identified in human plasma

A 2019 meta-analysis by Wei et al 11 reviewed the results of 4 RCTs on the use of onabotulinumtoxinA for TN and noted a significant improvement in reported pain values in comparison with placebo, with an estimated number needed to treat of 1.9 to achieve a 50% reduction in pain intensity

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COWS is becoming more popular as many stable patients are sent home from the ED and instructed to monitor for their own opioid withdrawal symptoms