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The expression of malondialdehyde (MDA) H 2 O 2 was significantly increased in the paw tissue of CIA mice, and intervention with curarelinone, the active ingredient of bitter ginseng, significantly inhibited oxidative damage and decreased the phosphorylation levels of signal transducer and activator of transcription (STAT)1, STAT3, and ratio of Th1 and Th17 cells in lymph nodes (62)

ROS-induced DNA damage, genomic instability, and altered signaling pathways have all been implicated in the initiation and promotion of lung carcinogenesis [15,16,17]

How Many Doses are Needed

Mild, moderate and severe: terminology implications for clinical and experimental traumatic brain injury