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In conclusion, the future of ROS-based immunotherapy will not depend on globally altering systemic redox balance, but on the precise, spatially resolved reprogramming of cellular redox states

This breakdown destabilizes the nanoparticles, leading to selective drug release inside the cells

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J Stem Cells 11(1):2536 Bloor AJC, Patel A, Griffin JE, Gilleece MH, Radia R, Yeung DT et al (2020) Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study