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Diabetic polyneuropathy in type 2 diabetes mellitus: inflammation, oxidative stress, and mitochondrial function

Enterobacteriaceae , although typically present in small numbers, can proliferate during dysbiosis, exacerbating inflammation due to the pyrogenic properties of LPS, which can intensify chronic inflammatory diseases, such as ulcerative colitis, Crohns disease, and even autoimmune diabetes ( The metabolic pathways of the body, particularly glucose and lipid metabolism, are also affected by microbial imbalance in the gut and may contribute to obesity, insulin resistance, and other metabolic disorders ( Faecalibacterium prausnitzii and Roseburia homini s, during dysbiosis diminishes SCFA production, which can further weaken the gut barrier and impair immune function

and transformation of muscle fibers from type I (slow twitch) to type II (fast twitch), particularly type IIB, which possess less oxidative capacity than type IIA or type I fibers

Analysis of risk factors for the association of sarcopenia in patients with type 2 diabetes mellitus