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28-31 These findings imply that there might be a common central pathogenesis and pathophysiology for these disorders

however, its production can be negatively affected by pollution with Cd and other HMs in the environment, which cause oxidative stress and toxicity

(3) Condensation of the tail and head group: Once both the benzoquinone head group precursor (4-HB) and the isoprenoid side chain (polyprenyl pyrophosphate, PPP) are synthesized, the enzyme COQ2 catalyzes their condensation via an electrophilic aromatic substitution 33