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Similarly, in neurodegenerative diseases such as Alzheimers disease (AD) and Parkinsons disease (PD), impaired clearance of toxic protein aggregates and defective mitophagy contribute to pathogenesis

However, people who exercise regularly naturally produce more antioxidants in the muscle to prevent damage, possibly in response to the regular formation of oxidative free radicals

PMID: 23734997

Cell Transplant 25(5):849861 Matsuyama N, Shimizu S, Ueda K, Suzuki T, Suzuki S, Miura R, Katayama A, Ando M et al (2022) Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia (SHIELD trial): a clinical trial protocol open-label, non-randomised, dose-escalation trial