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Hydroquinone and other skin lighteners work for those with dark pigmentation under their eyes (although do seek a doctors opinion first because usually darkness under the eyes is actually very thin skin with blood vessels showing through it and lightening agents will not help, but could hurt thin skin) 5

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

78% were White,16% were Asian, 2.9% were Hispanic or Latino, 2.1% were Black or African American, and 80 mL/min following concomitant administration of ibuprofen (OAT3 inhibitor) 400 mg four times a day

It does not recommend an amount, product or protocol.