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To calculate the cell viability, the cultured cells were uniformly distributed (1 10 3 cells/well) in a cell culture plate and incubated for the next 24 h, and subsequently treated with different concentrations (101000 g/mL) of test and control compounds for the next 5 days similar to cell culture conditions

In Chinese patients, p.P992L or p.N1270S was associated with presentation before age 12, and p.I1148T occurred almost exclusively in patients presenting after 12 yearsold

The peptide also demonstrates notable tachyphylaxis at the pituitary level repeated dosing leads to progressively diminished GH responses, attributed to GHSR desensitization, while cardiac CD36-mediated effects appear more sustained

Liver-specific Phb1 -KO mice have liver injury at a very young age, abnormal mitochondria and increased oxidative stress