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Ribatti, D., Nico, B., Crivellato, E

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There are various immunotherapeutic options available, including immunocheckpoint inhibitors (ICIs), inhibitors of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death receptor-1 (PD-1), as well as inhibitors of programmed death receptor-ligand 1 (PD-L1) ( Remodeling of tumour microenvironment in TNBC Multiple immunological and non-immune cell types contribute to long-lasting inflammation and localised immune suppression in this immune-modified milieu, allowing malignant cells to divide and mutate without being recognised and stopped by the hosts defense system ( Figure 2 ) ( Figures 2 , 3 ) ( Figure 3 ) ( Figure 4 ) ( Figure 2 Figure 3 Figure 4 TAFs in remodeling of tumour microenvironment TAFs (Tumour-Associated Fibroblasts) can activate in TNBC and release cytokines and growth factors that encourage tumour cell growth, invasion, and resistance to treatment ( Figure 4 )

Furthermore, there is a correlation between elevated mortality and severe CVD symptoms and indications and a rise in TMAO levels