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Frataxin as a Kinetic Activator of Persulfide Transfer to ISCU Biochemical Assays Point to an Acceleration of Persulfide Transfer by Frataxin To establish the physiological function of FXN in Fe-S cluster biogenesis, the FDX2-based reaction was studied in a stepwise manner (Gervason et al., 2019)

Due to the substrate specificity of different esterases, the enzymatic consideration should be systematically incorporated into the early design stage