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Based on previous studies with porphyrin binding maize GSTUs, this failure to bind these metabolites in planta is most likely because GSTU19 is predominantly expressed in the cytosol whereas these metabolites are synthesized in the chloroplast ( Our studies shed further light on the ability of plant GSTs to bind, and in some cases glutathione-conjugate natural and synthetic ligands, which may well influence the availability, and biological activity of such ligands

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Persistent cloudiness may indicate contamination or degradation

Combining antiangiogenic agents, such as saikosaponin b2 which targets the VEGF/ERK/HIF-1 pathway, with immunotherapy enhances treatment efficacy