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Description

Absence of Lewy pathology associated with PINK1 homozygous mutation

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As a result, at the end-stage, the failing heart contains about 30% less ATP than a healthy heart and also exhibits a lower PCr content [143], PCr being generated by creatine kinase from ATP and acting as an energy storage molecule and an energy transport compound (for further details see [144])

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MAP1643 encodes an isocitrate lyase, an essential enzyme that mediates the cleavage of isocitrate to succinate and glyoxylate, a part of glyoxylate shunt or the tricarboxylic acid cycle (TCA cycle)

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