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Important for tissue healing and repair, though also a concern in cancer contexts where new vessels can supply tumors

The RGDfK peptide-camptothecin conjugate linked by a Lys splitter enhanced cytotoxicity to melanoma and non-small cell lung cancer cells 80

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The absence of a significant effect with CBBBP alone suggests that the CBBBP construct may require the DSIP component to engage with the relevant neural pathways effectively