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Exploratory outcomes (observational follow-up phase: 12th to 24th week) 1) Therapeutic response of the control side: The change in key outcome measures (the size of the erosion area, REU/RHU scores, VAS, periodontal clinical parameters) on the original control side will be calculated using the 12-week assessment as the new baseline and the 24-week assessment as the endpoint, following the administration of delayed periodontal therapy

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Elevated intracellular cAMP levels activate protein kinase A (PKA), an enzyme that phosphorylates multiple target proteins

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