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Description

Chronic administration can sometimes lead to different responses compared to acute exposure, including potential receptor desensitization or cumulative effects

Aging: As skin ages, it may develop uneven pigmentation and dark spots

Additionally, nuclear receptor coactivator 4 (NCOA4) binds to ferritin and promotes ferritinophagy, releasing labile Fe 2+ into the LIP and facilitating ferroptosis

Construction of a ferroptosis-associated circRNA-miRNA-mRNA network in age-related macular degeneration

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