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While demonstrating significant advantages, DJX-A-KM has limitations, substoichiometric activity common to irreversible covalent degraders, potential off-target interactions from the flexible prolinol-acrylamide moiety

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One such intermediate byproduct is a potent toxin known as acetaldehyde. While acetaldehyde is short-lived, usually existing in the body only for a brief time before it is further broken down into acetate, according to a NIAAA fact sheet, it has the potential to cause significant damage to your cells and tissues in the liver, pancreas, brain and elsewhere