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63 Role of inflammasome activation in APAP-induced liver injury Inflammasome activation has been implicated in the pathogenesis of various hepatic and systemic inflammatory diseases, including nonalcoholic fatty liver disease, 6769 alcoholic liver disease, 70,71 viral hepatitis, 72 and sepsis-induced liver injury

Its primary mechanisms include the inhibition of oxidative stress, apoptosis, liver fibrosis, inflammation, and pyroptosis, effects closely associated with activation of the Nrf2 signaling pathway [53]

The level of GSR, an essential enzyme that recycles oxidized glutathione (GSSG) back to the reduced form (GSH), was significantly decreased in CKD5 as compared to CVD2 (Figures 3A, I)

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