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Isoprenoids generated by this pathway are essential for the activation and function of immune cells, including T cells, B cells, and macrophages

Abbreviations mtDNA: Mitochondrial DNA cGAS: Cyclic GMPAMP synthase STING: Stimulator of interferon genes TLR: Toll-like receptors DAMP: Damage-associated molecular pattern NDDs: Neurodegenerative diseases AD: Alzheimers disease PD: Parkinsons disease HD: Huntingtons disease ALS: Amyotrophic lateral sclerosis OXPHOS: Oxidative phosphorylation ROS: Reactive oxygen species ETC: Electron transport chain POLG: Polymerase gamma mPTP: Mitochondrial permeability transition pore OMM: Outer mitochondrial membrane CypD: Cyclophilin D MOMP: Mitochondrial outer membrane permeabilization PRR: Pattern recognition receptors EV: Extracellular vehicles cGAMP: Cyclic GMPAMP TBK1: TANK-binding kinase 1 IRF3: Interferon regulatory factor NLRP3: NOD-, LRR-, and pyrin domain-containing protein 3 PAMP: Pathogen - associated molecular patterns ASC: Apoptosis-associated speck-like protein containing a CARD NF-: Nuclear factor kappa beta MAPKs: Mitogen-activated protein kinases TNF-: Tumor necrosis factor-alpha References Prinz M, Priller J