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Growing approaches targeting lysosomal proteolysis Similar to the precise targeting of proteasomal proteolysis, several technologies targeting protein degradation through lysosomal proteolysis have emerged spontaneously, including autophagy-targeting chimera (AUTAC), newly developed AUTOTAC, autophagosome-tethering compound (ATTEC), CMA-targeting motif (CTM)-directed protein degradation, and lysosome-targeting chimera (LYTAC)

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Younossi ZM, Wong VWS, Anstee QM, Romero-Gomez M, Trauner MH, Harrison SA, Lawitz EJ, Okanoue T, Camargo M, Kersey K, Myers RP, Goodman Z, Stepanova M