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It can promote tissue repair, reduces inflammation, enhances angiogenesis (new blood vessel formation), and remains stable in gastric juice enabling effective oral administration

Additionally, SIRT1 inhibits alcohol-mediated inflammation through the NF-B pathway and decreases the expression of fibroblast markers, thereby alleviating liver fibrosis (Liu et al., 2022)

To further investigate mitochondrial function, proteins involved in the oxidative phosphorylation pathway were analyzed

Iron overload increases ferritin levels and decreases RUNX2 levels in BMSCs, causing irregular morphological changes, significantly reducing their activity, and inhibiting osteogenic differentiation, while melatonin therapy could reverse this process and promote osteogenic differentiation of BMSCs