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In MM, CD4 + and CD8 + T-cells form the primary immune defense, however, tumor-induced remodeling of the TME is unfavorable to T-cells due to nutrient deprivation, acidosis, and the accumulation of toxic metabolites (146) ( Figure 1 )

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We used four tumor-normal pairs for training, and evaluated the prediction performance on test sets consisting of the two remaining pairs, constituting a threefold cross-validation