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J Am Chem Soc 87:32753276

This would be especially true within the cytosol and its abundance of thiols, as HOCl is able to react with those at exceptionally high rates of more than 10 8 M 1 s 1 [229]

Furthermore, a crystal structure of Kap95p bound to human Ran-GTP 44 revealed an open conformation of Kap95p, in which the C-terminal domain moves away from the closed solenoid seen in the complex with the IBB domain