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Diabetes constituted the majority of indications (n = 16,863, 58.2%), followed by weight control (n = 1,352, 4.7%) and non-diabetic blood glucose abnormalities (n = 556, 1.9%)

Fillers, Thread Lifts, Non-Surgical Skin Tightening treatments (Ultherapy, Sofwave, Thermage, Exillis Ultra), and Plastic Surgery (facelift or fat transfer filling) are all options to eliminate smile lines

The mechanisms are fundamentally different, and that difference has significant clinical implications

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