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Moreover, interindividual heterogeneity driven by genetic variation (particularly VDR polymorphisms), metabolic comorbidities, and chronic low-grade inflammation further confounds the predictability of therapeutic efficacy

( b ) Compounds were assessed for anti-cancer activity at a concentration of 100 g/mL in four different human cell lines including H1437 (lung adenocarcinoma), Caco-2 (colorectal adenocarcinoma), LNCaP (prostate adenocarcinoma), and Huh7 (hepatocellular carcinoma)