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Although vancomycin has been linked to hepatic injury in case reports, evidence for its role in causing severe multisystem toxicity remains limited ( Tislelizumab, a PD-1 inhibitor, carries a recognized risk of immune-related hepatitis (irH) ( The patient reported chronic heavy alcohol intake (~200 g/day), which is recognized as a susceptibility factor in RUCAM and was incorporated into the risk-factor domain together with age 55 years (maximum contribution)

Around 15 dpc, CTB at the tips of anchoring villi rapidly proliferate, detach from villi columns, and differentiate into EVT ( The role of placenta in maintenance of pregnancy The placenta performs numerous vital biological functions, including nutrient and waste transfer, gas exchange, and the transmission of maternal immunoglobulins to the fetus, providing passive immunity ( The placenta also acts as a safeguard against the vertical transmission of infectious agents

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