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Conclusion: These promising findings advocate for the therapeutic potential of HepLPCs as an innovative strategy for liver cirrhosis, warranting further exploration through clinical trials, particularly in decompensated cirrhosis and acute-on-chronic liver failure patients

Disclosure of interest: Nothing to disclosure E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P2594 - ESOC25-2450 CONSEQUENCE OF EARLY AND LATE THROMBOLYSIS FOLLOWING ISCHEMIC STROKE ON BRAIN METABOLIC PROFILES EVALUATED BY 9.4 T MR SPECTROSCOPY Henrik Andersson 1 , Kajsa Arkelius 1 , Michael Gottschalk 1 , Saema Ansar 1 1 Lund University, Lund, Sweden Background and Aims: Ischemic stroke is a significant contributor to mortality and disability worldwide

Elevated iron levels can lead to the formation of hydroxyl radicals through the Fenton reaction, particularly when combined with hydrogen peroxide

Likewise, treatment of aortic SMCs with IL-1 or IL-6 caused a dose-dependent increase in alkaline phosphatase activity and increased cell mineralization in vitro (196)