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Abstract Background Drug-induced liver injury (DILI) is a significant adverse drug reaction, manifesting through a range of clinical presentations from mild liver enzyme to acute liver failure

4.2 Nanoparticle platforms: fabrication, properties, and translational challenges 4.2.1 Lipid-based nanoparticles (LBNs) 4.2.1.1 Solid lipid nanoparticles (SLNs) Solid lipid nanoparticles (SLNs), which are unilamellar lipid-based nanoparticles, constitute a well-established and highly versatile class of lipid nanoparticles owing to their solid hydrophobic lipid core, which effectively accommodates both hydrophobic and hydrophilic therapeutic agents (Satapathy et al., 2021)