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In Arabidopsis, SIR is encoded by a single, essential gene and is described as a bottleneck in the sulfate assimilation pathway ( SIR expression is rapidly upregulated in Arabidopsis and tomato in response to higher sulfite content, and accordingly SIR activity increases (Yarmolinsky et al., 2013)

Figure 2 4.1 Host attachment and colonisation In all disease contexts, nasopharyngeal colonisation by NTHi is a critical antecedent of subsequent ear and lower airway infections (Hare et al., 2010