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The bodys defense against oxidative stress can be achieved through the antioxidant activity of micronutrients (minerals and vitamins) and the interconnected systems of enzymes, which can eliminate or inhibit the formation of free radicals or repair damage caused by free radicals, thereby protecting the body from the harmful effects of oxidative stress and potentially preventing disease onset (13, 14)

A study (Di Francesco et al., 2015) showed that the expression level of DNA methyltransferase 1 (DNMT1) increased in AD patients over 65 years old and was related to the expression of the AD risk gene APOE4

Thus, GnRH agonists during chemotherapy maintain the therapeutic effect of the chemotherapeutic agent and protect the ovarian function

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