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Similar to cagrilintide, pramlintide is primarily eliminated via the kidneys and, in a pharmacokinetic study in participants with type 1 diabetes, no statistically significant differences were noted in total (AUC 0- ) and peak ( C max ) exposure after administration of a single pramlintide 60 g dose in participants with mild, moderate or severe renal impairment compared with those with normal renal function, although inter-patient variability was high [20]

Both are within the 28-day stability window

i.p.), pupils were dilated with tropicamide (Mydriacyl 1% Alcon, United Kingdom) two drops in both eyes, and then anesthetized with tetracaine drops (Tetracaine, Pliva, Zagreb, Croatia) in both eyes