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Nonetheless, oxidative stress and abnormal immune response are now recognized as important variables among several possible pathogenic components that may be crucial in controlling the chronic and persistent challenges observed in PCC individuals 22,23

6,10 In immunocompromised individuals, more unusual presentations can sometimes be observed

While transient, moderate activation is protective, chronic or excessive activation carries significant risks

Parenchymal astrocytes (protoplasmic, fibrous, Bergmann glia, Mller glia and so on) establish intricate contacts with synapses, creating a multipartite (and multicellular) synaptic complexalso known as the synaptic cradlethat oversees synaptogenesis, synaptic maturation, maintenance and extinction 21,22,23,24