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Despite the initial shift toward glycolysis, microglia in advanced stages of Alzheimer's disease experience a decline in both glycolytic and oxidative phosphorylation pathways, resulting in a state of energetic exhaustion that impairs their ability to clear debris and protect neurons (103)

Together, these results suggest that there is an interaction between NLGN4X and three out of four toxins compounds tested (Aflatoxin B2, gliotoxin and deoxynivalenol), as predicted by the computational approach, whereas for Aflatoxin B1, the predicted binding with NLGN4X was not confirmed by this assay

Gaurav V, Paliwal S, Singh A, Pandey S, Aqil M

However, this is not the primary mechanism of weight loss