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GHRPs instead act as a parallel, ghrelin-mimetic pathway which is why the two classes are frequently combined in stimulation-testing protocols, where their synergistic effect on GH output exceeds either compound alone

Specifically, there is a focus on the effective role and mechanism of the small molecule secretory protein thioredoxin (Trx) that is widely expressed in lung tissues such as the type II alveolar cells, macrophages and bronchial epithelium

If excessive ROS is produced by oxygen enzymes along the respiratory chain, it will cause DNA damage, protein crosslinking, lipid peroxidation of polyunsaturated fatty acids and further lead to cell aging, cell membrane damage, etc

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