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A 2.29-fold increase ranks this gene among the top eight most affected by BPC-157 treatment in microarray analysis

In the granulosa cells of patients with PCOS and in letrozole-induced rat models, the HIF-1/BNIP3 mediated mitophagy is suppressed, resulting in a decrease in the clearance capacity of damaged mitochondria and accumulation of ROS, thereby inducing mitochondrial dysfunction [71]

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Abstract Tumor necrosis commonly exists and predicts poor prognoses in many cancers