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Additionally, NAC cleaves disulfide bonds in proteins, especially in mucin glycoproteins, thereby reducing mucus viscosity and exerting mucolytic effects ( Beyond these well-established clinical indications, NAC exhibits a wide range of pleiotropic effects, including regulation of mitochondrial function, reduction of inflammation and oxidative stress, modulation of apoptosis, and antimicrobial activity through inhibition of biofilm formation in the lungs ( 4 Effects of the combined application of hyperbaric oxygen therapy and N-acetylcysteine In all studies presented, HBOT was administered using clinically relevant protocols, with pressures ranging from 2 to 2.8 ATA and session durations of 60120 min, applied as acute, single, or intermittent treatments (48)

They are adjunctive, not foundational

The entry of cisplatin into the inner ear leads to the formation of inner ear cellular damage products (DAMPs), which, together with cisplatin, bind to toll-like receptors (TLRs) (Wang L

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