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Cons: Limited Clinical Evidence: While there is promising anecdotal evidence and animal studies, human clinical trials are limited

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Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease

In addition, a study has shown that in atrial appendages of patients undergoing cardiac procedures, increased levels of endothelial nitric oxide synthase can promote many cardiovascular phenotypes, including atrial fibrillation, during endothelial cell dysfunction