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395 The loss of double-strand repair pathway due to BRCA1 or BRCA2 mutations renders cancer cells more dependent on the PARPs-mediated repair, and more sensitive to PARP inhibition, raising a possibility of a wider application of PARPi in cancer therapy

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Triggers of IL-1 production have been observed in a number of different stimuli, such as sulfur mustard, nickel, contact allergens or superantigens 36 IL-1 stimulates further release of secondary mediators, including IL-8

Zhou B, Yu P, Lin M-Y et al (2016) Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits