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Recently, it has been reported that oral administration of 1 g/day of vitamin C for a period of 16 weeks resulted in the reduction of serum levels of malondialdehyde and elevation of glutathione peroxidase levels among the patients on maintenance hemodialysis (34)

These research findings highlight the importance of MLL4 and ALOX12B in skin health

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Furthermore, inhibition of Rac1 activity by Rhein not only reduces oxidative stress but also affects downstream signaling pathways involved in EMT and renal fibrosis, such as the -catenin pathway (Xiong et al., 2023)