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For that, we used the pathway activity analysis tool PROGENy 41 , which calculates pathway activity scores based on pathway regulons: a set of genes whose expression is influenced by pathway activation or inhibition

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Patients were assessed at baseline and after 3 months of starting KD, the assessments of children included: 24-hour dietary recall, Chalfont Seizures Severity Scale, gastrointestinal symptoms score and Bristol stool chart, frequency of defecation per week, anthropometric measurements assessment, fasting serum lipid profile and measurement of the antral length by ultrasound