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Given the low bioavailability of oral GSH, researchers have supplemented with compounds that directly or indirectly affect the GSH system

For example, TGF-s, bone morphometric proteins (BMPs) and their related peptides, such as P24 and P20, mediate the differentiation of osteoblasts and chondrocyte lineages via both Smad-dependent and Smad-independent signaling pathways, but they recruit distinct receptor heterotetramers and R-Smad complexes, thus exerting different biological effects on osteogenesis, osteoclastogenesis, and chondrogenesis [167]

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There is an increasing inclination towards employing these natural metabolites as complementary strategies in the prevention and treatment of MI