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Areas with lower-selenium soil have been linked to increased Hashimoto thyroiditis in humans (104)

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Subsequently, RNA sequencing was utilised to investigate transcriptomic changes post-vaccination

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The only alteration we made was the replacement of Met1 by its bioisostere norleucine (Nle) to avoid the notorious oxidation of the Met1 thioether moiety, leading to different molecular weights (M, M+16Da and M+32Da) for a single type of Ub protein, which is detrimental to MS analysis and quantification

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