how does glutathione s-transferase cause drug resistance in cancer cells

how does glutathione s-transferase cause drug resistance in cancer cells The Multifaceted Role of S-Transferases Health and Disease Role of Glutathione in Cancer:

Name: how does glutathione s-transferase cause drug resistance in cancer cells The Multifaceted Role of S-Transferases Health and Disease Role of Glutathione in Cancer:
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Role of Glutathione in Cancer: From Mechanisms to Therapies Overcoming resistance to cisplatin by inhibition of glutathione S transferases (GSTs) with ethacraplatin micelles in vitro and in vivo ScienceDirect The role of glutathione S transferase in anti cancer drug resistance Oncogene System Xc GSH GPX4 axis: An important antioxidant system for the ferroptosis in drug resistant solid tumor therapy PMC

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Similarly, in OA, this mechanism may contribute to pathological processes, such as aberrant subchondral bone remodeling and osteophyte formation, by amplifying the bone resorption-formation imbalance, although its deeper mechanisms require further investigation