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The activated SMAD2/3 complex is then coupled to SMAD4 for nuclear translocation, where the SMAD complex binds its target genes and drives their expression together with a number of different transcription factors [16]

This combined approach elucidates the complex interactions between bioactive compounds and biological networks, ultimately helping to uncover the mechanisms underlying their antidepressant effects [543]

The anti-inflammatory mechanism of the peel of Zanthoxylum piperitum DC is by suppressing NF-B/Caspase-1 activation in LPS-induced RAW264.7 cells