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DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics

Vitamin B12 deficiency causes megaloblastic anaemia and a progressive peripheral neuropathy that can be irreversible if not treated

Due to nutrients deficiency can reason of various health problems like defective bone growth, digestive issues, skin disorders, and dementia (memory loss)

Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany NNMT inhibition, establishing a fuller picture of the enzyme's regulatory network