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eBioMedicine (2020) 61:103104

Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis

But challenges, like fake candidates and skyrocketing benefit costs, are on the horizon

Beyond MTHFR, polymorphisms in genes encoding drug transporters, such as SLC19A1 (rs1051266) and SLCO1B1 (SLCO1B15 and SLCO1B115), have been implicated in MTX transport efficiency and toxicity profiles