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It needs the ability to make it

Moreover, following ACMG guidelines (Richards et al., 2015) a large proportion of variants can be classified as of uncertain significance (VUS) or benign, without considering their additive burden in shaping polygenic phenotypes

2.7 Endothelial function and vascular health HGH is directly involved in maintaining vascular health, primarily through stimulating nitric oxide (NO) production, a short-lived gas considered an essential vasodilator