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[DOI] [PubMed] [Google Scholar] 82.Carassiti D, Altmann DR, Petrova N, Pakkenberg B, Scaravilli F, Schmierer K

Pharmacological management Despite advancements in therapy over the past two decades, pharmacotherapy remains the mainstay of treatment with surgery reserved for refractory cases[1]

The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion