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Additionally, light can influence sleep through circadian-independent pathways by regulating preoptic area circuits that promote non-REM sleep without affecting REM sleep 11

Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain

Moreover, various pathological changes can emerge together, in sequence or in isolation being disease-, stage-, and context-specific, and are influenced by age and systemic pathologies